Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Biological Context
Subcellular Location: Cell membrane (Single-pass type II membrane protein)
Tissue Specificity: Brain, liver, placenta, lymphocytes and erythrocytes
Disease Association: Schizophrenia (SCZD) : A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. [Disease susceptibility may be associated with variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Catechol O-methyltransferase (COMT), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 52-271aa, with N-terminal 6xHis-tagged tag, molecular weight 28.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications. Explore more Enzyme proteins →
