Recombinant Human Cathepsin D (CTSD), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 40.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Cathepsin D (CTSD), partial

Recombinant Human Cathepsin D (CTSD), partial — Acid protease active in intracellular protein breakdown. Purity >90%.

SKU: BCRECP-000454 Category:
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Product Specifications

Product SkuBCRECP-000454
Product DescriptionRecombinant Human Cathepsin D (CTSD) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 67-403aa. [Accession | P07339].
Uniprot No.P07339
Gene NamesCTSD
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region67-403aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight40.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

Biological Context

Subcellular Location: Lysosome; Melanosome; Secreted, extracellular space
Tissue Specificity: Expressed in the aorta extracellular space (at protein level). Expressed in liver (at protein level)
Disease Association: Ceroid lipofuscinosis, neuronal, 10 (CLN10) : A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Cathepsin D (CTSD), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 67-403aa, with N-terminal 6xHis-tagged tag, molecular weight 40.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease

Subcellular Location

Lysosome; Melanosome; Secreted, extracellular space

Disease Association

Ceroid lipofuscinosis, neuronal, 10 (CLN10) : A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530)

Subunit

Consists of a light chain and a heavy chain (PubMed:1426530, PubMed:8393577). Interacts with ADAM30; this leads to activation of CTSD (PubMed:27333034). Interacts with GRN; stabilizes CTSD; increases its proteolytic activity (By similarity)

Gene: CTSD  |  Organism: Homo sapiens
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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