Recombinant Human Cathepsin K (CTSK), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 27.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Cathepsin K (CTSK)

Recombinant Human Cathepsin K (CTSK) — Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Purity >90%.

SKU: BCRECP-000456 Category:
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Product Specifications

Product SkuBCRECP-000456
Product DescriptionRecombinant Human Cathepsin K (CTSK) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 115-329aa. [Accession | P43235].
Uniprot No.P43235
Gene NamesCTSK
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region115-329aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight27.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

Biological Context

Subcellular Location: Lysosome; Secreted; Apical cell membrane (Peripheral membrane protein)
Tissue Specificity: Predominantly expressed in osteoclasts (bones). Expressed in thyroid epithelial cells
Disease Association: Pycnodysostosis (PKND) : A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Cathepsin K (CTSK) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 115-329aa, with N-terminal 6xHis-tagged tag, molecular weight 27.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042)

Subcellular Location

Lysosome; Secreted; Apical cell membrane (Peripheral membrane protein)

Disease Association

Pycnodysostosis (PKND) : A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Predominantly expressed in osteoclasts (bones) (PubMed:7805878). Expressed in thyroid epithelial cells (PubMed:11082042)

Gene: CTSK  |  Organism: Homo sapiens  |  Synonyms: Cathepsin O; Cathepsin O2; Cathepsin X
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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