Recombinant Human CCN family member 2 (CCN2), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 15.1kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human CCN family member 2 (CCN2), partial

Recombinant Human CCN family member 2 (CCN2), partial — Major connective tissue mitoattractant secreted by vascular endothelial cells. Purity >90%.

SKU: BCRECP-000256 Category:
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Product Specifications

Product SkuBCRECP-000256
Product DescriptionRecombinant Human CCN family member 2 (CCN2) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 253-349aa. [Accession | P29279].
Uniprot No.P29279
Gene NamesCCN2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region253-349aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight15.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis.

Biological Context

Subcellular Location: Secreted, extracellular space, extracellular matrix; Secreted
Tissue Specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested
Disease Association: Kyphomelic dysplasia (KMD) : An autosomal recessive skeletal dysplasia characterized by bowing of the limbs primarily affecting the femora, along with short stature, short and wide iliac wings, horizontal acetabular roof, platyspondyly, metaphyseal flaring and distinctive facial features that include prominent forehead, micrognathia, microstomia, cleft palate and low set ears. [The disease may be caused by variants affecting the gene represented in this entry] | Spondyloepimetaphyseal dysplasia, Li-Shao-Li type (SEMDLSL) : A form of spondyloepimetaphyseal dysplasia, a clinically and genetically heterogeneous group of skeletal disorders marked by vertebral, epiphyseal, and metaphyseal abnormalities. SEMDLSL is an autosomal dominant form characterized by childhood onset of defective skeletal development. Affected individuals exhibit disproportionate short stature, short lower limbs, limited joint flexion, premature osteoarthritis-like changes in weight-bearing joints, and low bone mass. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human CCN family member 2 (CCN2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 253-349aa, with N-terminal 6xHis-tagged tag, molecular weight 15.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (PubMed:39414788). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis

Subcellular Location

Secreted, extracellular space, extracellular matrix; Secreted

Disease Association

Kyphomelic dysplasia (KMD) : An autosomal recessive skeletal dysplasia characterized by bowing of the limbs primarily affecting the femora, along with short stature, short and wide iliac wings, horizontal acetabular roof, platyspondyly, metaphyseal flaring and distinctive facial features that include prominent forehead, micrognathia, microstomia, cleft palate and low set ears. [The disease may be caused by variants affecting the gene represented in this entry] | Spondyloepimetaphyseal dysplasia, Li-Shao-Li type (SEMDLSL) : A form of spondyloepimetaphyseal dysplasia, a clinically and genetically heterogeneous group of skeletal disorders marked by vertebral, epiphyseal, and metaphyseal abnormalities. SEMDLSL is an autosomal dominant form characterized by childhood onset of defective skeletal development. Affected individuals exhibit disproportionate short stature, short lower limbs, limited joint flexion, premature osteoarthritis-like changes in weight-bearing joints, and low bone mass. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested

Subunit

Monomer (PubMed:1654338). Interacts with TSKU (PubMed:30232710)

Gene: CCN2  |  Organism: Homo sapiens  |  Synonyms: Cellular communication network factor 2; Connective tissue growth factor; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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