Recombinant Human Cocaine esterase (CES2) (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 60.3 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Cocaine esterase (CES2) (Active)

Recombinant Human Cocaine esterase (CES2) (Active) — Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Purity >95%.

SKU: BCACP-000341 Categories: ,
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Product SKUBCACP-000341
Product DescriptionRecombinant Human Cocaine esterase (CES2) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 27-559aa. [Accession | O00748].
Uniprot No.O00748
Gene NamesCES2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region27-559aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight60.3 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Human CEACAM1 at 2 μg/mL can bind Anti-CEACAM1 recombinant antibody . The EC50 is 0.3677-0.4528 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCocaine esterase; EC:3.1.1.84; Carboxylesterase 2 (CE-2; hCE-2) (EC:3.1.1.11); Methylumbelliferyl-acetate deacetylase 2 (EC:3.1.1.56); CES2;ICE

Function

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol.

Biological Context

Subcellular Location: Endoplasmic reticulum lumen
Tissue Specificity: Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum

Product Specifications

Recombinant Human Cocaine esterase (CES2) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 27-559aa, with C-terminal 10xHis-tagged tag, molecular weight 60.3 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA.Immobilized Human CEACAM1 at 2 μg/mL can bind Anti-CEACAM1 recombinant antibody . The EC50 is 0.3677-0.4528 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984)

Subcellular Location

Endoplasmic reticulum lumen

Tissue Specificity

Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum

Subunit

Monomer

Gene: CES2  |  Organism: Homo sapiens  |  Synonyms: Carboxylesterase 2; Methylumbelliferyl-acetate deacetylase 2
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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