Recombinant Human COMM domain-containing protein 4 (COMMD4), partial, Homo sapiens (Human), E.coli, N-terminal GST-tagged, 48.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human COMM domain-containing protein 4 (COMMD4), partial

Recombinant Human COMM domain-containing protein 4 (COMMD4), partial — Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Purity >90%.

SKU: BCRECP-000409 Category:
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Product Specifications

Product SkuBCRECP-000409
Product DescriptionRecombinant Human COMM domain-containing protein 4 (COMMD4) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-195aa. [Accession | Q9H0A8].
Uniprot No.Q9H0A8
Gene NamesCOMMD4
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-195aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight48.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B.

Biological Context

Subcellular Location: Cytoplasm; Nucleus
Tissue Specificity: Ubiquitous

Product Specifications

Recombinant Human COMM domain-containing protein 4 (COMMD4), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-195aa, with N-terminal GST-tagged tag, molecular weight 48.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B (PubMed:23637203)

Subcellular Location

Cytoplasm; Nucleus

Tissue Specificity

Ubiquitous

Subunit

Component of the commander complex consisting of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129, PubMed:25355947, PubMed:15799966). Component of the CCC (COMMD/CCDC22/CCDC93) subcomplex consisting of COMMD1, COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10, CCDC22 and CCDC93; within the complex forms a heterodimer with COMMD8 (PubMed:37172566, PubMed:38459129, PubMed:15799966, PubMed:23563313, PubMed:25355947). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL5, CUL7 (PubMed:15799966, PubMed:21778237, PubMed:23637203)

Gene: COMMD4  |  Organism: Homo sapiens
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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