Recombinant Human Contactin-associated protein-like 2 (CNTNAP2), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 20.5kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Contactin-associated protein-like 2 (CNTNAP2), partial

Recombinant Human Contactin-associated protein-like 2 (CNTNAP2), partial — Required for gap junction formation (Probable). Purity >95%.

SKU: BCRECP-000400 Category:
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Product Specifications

Product SkuBCRECP-000400
Product DescriptionRecombinant Human Contactin-associated protein-like 2 (CNTNAP2) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 35-181aa. [Accession | Q9UHC6].
Uniprot No.Q9UHC6
Gene NamesCNTNAP2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region35-181aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight20.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein); Cell projection, axon; Cell junction, paranodal septate junction
Tissue Specificity: Predominantly expressed in nervous system
Disease Association: Autism 15 (AUTS15) : A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate intellectual disability. [Disease susceptibility is associated with variants affecting the gene represented in this entry] | [A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2] | Pitt-Hopkins-like syndrome 1 (PTHSL1) : A syndrome characterized by severe intellectual disability and variable additional symptoms, such as impaired speech development, seizures, autistic behavior, breathing anomalies and a broad mouth, resembling Pitt-Hopkins syndrome. In contrast to patients with Pitt-Hopkins syndrome, PTHSL1 patients present with normal or only mildly to moderately delayed motor milestones. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Contactin-associated protein-like 2 (CNTNAP2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 35-181aa, with N-terminal 6xHis-tagged tag, molecular weight 20.5kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction

Subcellular Location

Membrane (Single-pass type I membrane protein); Cell projection, axon; Cell junction, paranodal septate junction

Disease Association

Autism 15 (AUTS15) : A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate intellectual disability. [Disease susceptibility is associated with variants affecting the gene represented in this entry] | [A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2] | Pitt-Hopkins-like syndrome 1 (PTHSL1) : A syndrome characterized by severe intellectual disability and variable additional symptoms, such as impaired speech development, seizures, autistic behavior, breathing anomalies and a broad mouth, resembling Pitt-Hopkins syndrome. In contrast to patients with Pitt-Hopkins syndrome, PTHSL1 patients present with normal or only mildly to moderately delayed motor milestones. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Predominantly expressed in nervous system

Subunit

Interacts (via C-terminus) with KCNA2 (PubMed:10624965). Interacts with GPR37 (PubMed:25977097)

Gene: CNTNAP2  |  Organism: Homo sapiens  |  Synonyms: Cell recognition molecule Caspr2
Key Publications

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