Recombinant Human Contactin-associated protein-like 2 (CNTNAP2), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 20.5kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Contactin-associated protein-like 2 (CNTNAP2), partial

Recombinant Human Contactin-associated protein-like 2 (CNTNAP2), partial — Required for gap junction formation (Probable). Purity >95%.

SKU: BCRECP-000400 Category:
Online Inquiry →

Product Specifications

Product SkuBCRECP-000400
Product DescriptionRecombinant Human Contactin-associated protein-like 2 (CNTNAP2) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 35-181aa. [Accession | Q9UHC6].
Uniprot No.Q9UHC6
Gene NamesCNTNAP2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region35-181aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight20.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein); Cell projection, axon; Cell junction, paranodal septate junction
Tissue Specificity: Predominantly expressed in nervous system
Disease Association: Autism 15 (AUTS15) : A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate intellectual disability. [Disease susceptibility is associated with variants affecting the gene represented in this entry] | [A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2] | Pitt-Hopkins-like syndrome 1 (PTHSL1) : A syndrome characterized by severe intellectual disability and variable additional symptoms, such as impaired speech development, seizures, autistic behavior, breathing anomalies and a broad mouth, resembling Pitt-Hopkins syndrome. In contrast to patients with Pitt-Hopkins syndrome, PTHSL1 patients present with normal or only mildly to moderately delayed motor milestones. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Contactin-associated protein-like 2 (CNTNAP2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 35-181aa, with N-terminal 6xHis-tagged tag, molecular weight 20.5kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction

Subcellular Location

Membrane (Single-pass type I membrane protein); Cell projection, axon; Cell junction, paranodal septate junction

Disease Association

Autism 15 (AUTS15) : A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate intellectual disability. [Disease susceptibility is associated with variants affecting the gene represented in this entry] | [A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2] | Pitt-Hopkins-like syndrome 1 (PTHSL1) : A syndrome characterized by severe intellectual disability and variable additional symptoms, such as impaired speech development, seizures, autistic behavior, breathing anomalies and a broad mouth, resembling Pitt-Hopkins syndrome. In contrast to patients with Pitt-Hopkins syndrome, PTHSL1 patients present with normal or only mildly to moderately delayed motor milestones. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Predominantly expressed in nervous system

Subunit

Interacts (via C-terminus) with KCNA2 (PubMed:10624965). Interacts with GPR37 (PubMed:25977097)

Gene: CNTNAP2  |  Organism: Homo sapiens  |  Synonyms: Cell recognition molecule Caspr2
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

Shopping Cart
Scroll to Top