Recombinant Human/Cynomolgus monkey Activin receptor type-2A (ACVR2A), partial (Active), Homo sapiens (Human), Yeast, C-terminal 10xHis-tagged, 15.5 kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human/Cynomolgus monkey Activin receptor type-2A (ACVR2A), partial (Active)

Recombinant Human/Cynomolgus monkey Activin receptor type-2A (ACVR2A), partial (Active) — On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Purity >90%.

SKU: BCACP-000346 Category:
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Product SKUBCACP-000346
Product DescriptionRecombinant Human monkey Activin receptor type-2A (ACVR2A) protein is expressed from Yeast with C-terminal 10xHis-tagged. It contains 20-135aa. [Accession | P27037].
Uniprot No.P27037
Gene NamesACVR2A
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region20-135aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight15.5 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized anti-protein L antibody at 2 μg/mL can bind Biotinylated Protein L. The EC50 is 1.123-1.761 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesActivin receptor type-2A; EC:2.7.11.30; Activin receptor type IIA (ACTR-IIA; ACTRIIA);ACVR2A; ACVR2

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Product Specifications

Recombinant Human/Cynomolgus monkey Activin receptor type-2A (ACVR2A), partial (Active) is a recombinant protein, expressed in Yeast, covering amino acids 20-135aa, with C-terminal 10xHis-tagged tag, molecular weight 15.5 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed:17911401, PubMed:10652306). Mediates induction of adipogenesis by GDF6 (By similarity)

Gene: ACVR2A  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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