Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 52.9 kDa, purity >90% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.

Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial (Active)

Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial (Active) — Receptor for thymic stromal lymphopoietin (TSLP). Purity >90%.

SKU: BCACP-000511 Category:
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Product SKUBCACP-000511
Product DescriptionRecombinant Human Cytokine receptor-like factor 2 (CRLF2) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 25-231aa. [Accession | Q9HC73].
Uniprot No.Q9HC73
Gene NamesCRLF2
PurityGreater than 90% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region25-231aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight52.9 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Human INSR at 2 μg/mL can bind Anti-INSR recombinant antibody .The EC50 is 6.703-9.229 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCytokine receptor-like factor 2; Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor (TSLP receptor); CRLF2; CRL2, ILXR, TSLPR

Function

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells

Product Specifications

Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 25-231aa, with C-terminal hFc1-tagged tag, molecular weight 52.9 kDa, purity Greater than 90% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA.Immobilized Human INSR at 2 μg/mL can bind Anti-INSR recombinant antibody .The EC50 is 6.703-9.229 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system

Subcellular Location

Secreted

Tissue Specificity

Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells

Subunit

Heterodimer of CRLF2 and IL7R

Gene: CRLF2  |  Organism: Homo sapiens  |  Synonyms: Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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