Recombinant Human cytomegalovirus Protein UL141 (UL141), partial, Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 35.2kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human cytomegalovirus Protein UL141 (UL141), partial

Recombinant Human cytomegalovirus Protein UL141 (UL141), partial — Evasion of NK cell killing. Purity >90%.

SKU: BCRECP-004679 Categories: ,
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Product Specifications

Product SkuBCRECP-004679
Product DescriptionRecombinant Human cytomegalovirus Protein UL141 (UL141) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 37-278aa. [Accession | Q6RJQ3].
Uniprot No.Q6RJQ3
Gene NamesUL141
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region37-278aa
SpeciesHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight35.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface.

Biological Context

Subcellular Location: Host endoplasmic reticulum membrane (Single-pass type I membrane protein)

Product Specifications

Recombinant Human cytomegalovirus Protein UL141 (UL141), partial is a recombinant protein from Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5), expressed in E.coli, covering amino acids 37-278aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 35.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand NECTIN2 for proteasome-mediated degradation. Additionally promotes intracellular retention of TNFRSF10A/TRAIL-R1 and TNFRSF10B/TRAIL-R2 and thus down-regulates their cell surface expression

Subcellular Location

Host endoplasmic reticulum membrane (Single-pass type I membrane protein)

Subunit

Interacts with human PVR. Interacts with human TNFRSF10A and TNFRSF10B. Forms a homodimer that engages two TNFRSF10B monomers

Gene: UL141  |  Organism: Human cytomegalovirus (strain Merlin)
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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