Recombinant Human cytomegalovirus Protein UL141 (UL141), partial, Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 35.2kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human cytomegalovirus Protein UL141 (UL141), partial

Recombinant Human cytomegalovirus Protein UL141 (UL141), partial — Evasion of NK cell killing. Purity >90%.

SKU: BCRECP-004679 Categories: ,
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Product Specifications

Product SkuBCRECP-004679
Product DescriptionRecombinant Human cytomegalovirus Protein UL141 (UL141) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 37-278aa. [Accession | Q6RJQ3].
Uniprot No.Q6RJQ3
Gene NamesUL141
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region37-278aa
SpeciesHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight35.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface.

Biological Context

Subcellular Location: Host endoplasmic reticulum membrane (Single-pass type I membrane protein)

Product Specifications

Recombinant Human cytomegalovirus Protein UL141 (UL141), partial is a recombinant protein from Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5), expressed in E.coli, covering amino acids 37-278aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 35.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand NECTIN2 for proteasome-mediated degradation. Additionally promotes intracellular retention of TNFRSF10A/TRAIL-R1 and TNFRSF10B/TRAIL-R2 and thus down-regulates their cell surface expression

Subcellular Location

Host endoplasmic reticulum membrane (Single-pass type I membrane protein)

Subunit

Interacts with human PVR. Interacts with human TNFRSF10A and TNFRSF10B. Forms a homodimer that engages two TNFRSF10B monomers

Gene: UL141  |  Organism: Human cytomegalovirus (strain Merlin)
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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