Recombinant Human Disintegrin and metalloproteinase domain-containing protein 33 (ADAM33), partial, Homo sapiens (Human), Baculovirus, C-terminal 6xHis-tagged, 78.0kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Disintegrin and metalloproteinase domain-containing protein 33 (ADAM33), partial

Recombinant Human Disintegrin and metalloproteinase domain-containing protein 33 (ADAM33), partial — Metalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation. Purity >90%.

SKU: BCRECP-000032 Category:
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Product Specifications

Product SkuBCRECP-000032
Product DescriptionRecombinant Human Disintegrin and metalloproteinase domain-containing protein 33 (ADAM33) Protein is expressed from Baculovirus with C-terminal 6xHis-tagged. It contains 30-701aa. [Accession | Q9BZ11].
Uniprot No.Q9BZ11
Gene NamesADAM33
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemBaculovirus
Expression Region30-701aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight78.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Metalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation. Modulates the activity of adhesion molecules and cytokines by generating soluble forms, leading to either attenuation of cell-surface signaling or initiation of downstream intracellular signaling pathways. For instance, acts as a constitutive sheddase of kit ligand/KITLG.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins
Disease Association: Asthma (ASTHMA) : The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. [Disease susceptibility is associated with variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Disintegrin and metalloproteinase domain-containing protein 33 (ADAM33), partial is a recombinant protein from Homo sapiens (Human), expressed in Baculovirus, covering amino acids 30-701aa, with C-terminal 6xHis-tagged tag, molecular weight 78.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Metalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation (PubMed:14676211, PubMed:33982767). Modulates the activity of adhesion molecules and cytokines by generating soluble forms, leading to either attenuation of cell-surface signaling or initiation of downstream intracellular signaling pathways. For instance, acts as a constitutive sheddase of kit ligand/KITLG (PubMed:14676211). Promotes and maintains a proliferative phenotype in vascular smooth muscle cells through regulation of the PI3K/AKT and ERK signaling pathways (PubMed:33982767). Additionally, enhances cell migration and regulates cytokine secretion during airway vascular remodeling via the same signaling cascades (PubMed:36091328)

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Disease Association

Asthma (ASTHMA) : The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. [Disease susceptibility is associated with variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins

Gene: ADAM33  |  Organism: Homo sapiens
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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