Recombinant Human Elongin-B (ELOB), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 40.1kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Elongin-B (ELOB)

Recombinant Human Elongin-B (ELOB) — (Microbial infection) Following infection by HIV-1 virus, component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitin… Purity >90%.

SKU: BCRECP-000585 Category:
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Product Specifications

Product SkuBCRECP-000585
Product DescriptionRecombinant Human Elongin-B (ELOB) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-118aa. [Accession | Q15370].
Uniprot No.Q15370
Gene NamesELOB
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-118aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight40.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

(Microbial infection) Following infection by HIV-1 virus, component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G. The complex can also ubiquitinate APOBEC3H to some extent.

Biological Context

Subcellular Location: Nucleus
Pathway: Protein modification; protein ubiquitination

Product Specifications

Recombinant Human Elongin-B (ELOB) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-118aa, with N-terminal GST-tagged tag, molecular weight 40.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Following infection by HIV-1 virus, component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G (PubMed:18562529, PubMed:20532212, PubMed:22190037, PubMed:24225024, PubMed:24402281, PubMed:36754086). The complex can also ubiquitinate APOBEC3H to some extent (PubMed:37640699)

Subcellular Location

Nucleus

Subunit

(Microbial infection) Interacts with herpes virus 8 virus protein LANA1

Pathway

Protein modification; protein ubiquitination

Gene: ELOB  |  Organism: Homo sapiens  |  Synonyms: Elongin 18 kDa subunit; RNA polymerase II transcription factor SIII subunit B; SIII p18; Transcription elongation factor B polypeptide 2
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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