Recombinant Human Enhancer of yellow 2 transcription factor homolog (ENY2), Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 18.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Enhancer of yellow 2 transcription factor homolog (ENY2)

Recombinant Human Enhancer of yellow 2 transcription factor homolog (ENY2) — Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. Purity >90%.

SKU: BCRECP-000593 Category:
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Product Specifications

Product SkuBCRECP-000593
Product DescriptionRecombinant Human Enhancer of yellow 2 transcription factor homolog (ENY2) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 1-101aa. [Accession | Q9NPA8].
Uniprot No.Q9NPA8
Gene NamesENY2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-101aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight18.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B.

Biological Context

Subcellular Location: Nucleus, nucleoplasm

Product Specifications

Recombinant Human Enhancer of yellow 2 transcription factor homolog (ENY2) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-101aa, with C-terminal 6xHis-tagged tag, molecular weight 18.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820)

Subcellular Location

Nucleus, nucleoplasm

Subunit

Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, the isoform GANP of the MCM3AP gene, PCID2, SEM1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex also associates with ALYREF/ALY and with the nucleoporin NUP153 (PubMed:22307388, PubMed:23591820). Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H/SPT3, TAF10, TRRAP and USP22 (PubMed:18206972, PubMed:21746879, PubMed:23591820, PubMed:27601583). Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module) (PubMed:18206972, PubMed:21746879, PubMed:27601583). Interacts with RNA polymerase II subunit POLR2A (PubMed:22307388). Interacts with ATXN7L3B (PubMed:27601583)

Gene: ENY2  |  Organism: Homo sapiens  |  Synonyms: Enhancer of yellow 2 transcription factor homolog
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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