Recombinant Human Epidermal growth factor receptor substrate 15 (EPS15), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 20.9kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Epidermal growth factor receptor substrate 15 (EPS15), partial

Recombinant Human Epidermal growth factor receptor substrate 15 (EPS15), partial — Involved in cell growth regulation. Purity >90%.

SKU: BCRECP-000599 Categories: ,
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Product Specifications

Product SkuBCRECP-000599
Product DescriptionRecombinant Human Epidermal growth factor receptor substrate 15 (EPS15) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 657-798aa. [Accession | P42566].
Uniprot No.P42566
Gene NamesEPS15
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region657-798aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight20.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR.

Biological Context

Subcellular Location: Early endosome membrane (Peripheral membrane protein)
Tissue Specificity: Ubiquitously expressed
Disease Association: [A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein]

Product Specifications

Recombinant Human Epidermal growth factor receptor substrate 15 (EPS15), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 657-798aa, with N-terminal 6xHis-tagged tag, molecular weight 20.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2

Subcellular Location

Early endosome membrane (Peripheral membrane protein)

Disease Association

[A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein]

Tissue Specificity

Ubiquitously expressed

Subunit

(Microbial infection) Interacts with vaccinia virus protein A36

Gene: EPS15  |  Organism: Homo sapiens  |  Synonyms: Protein AF-1p
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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