Recombinant Human Epidermal growth factor receptor substrate 15 (EPS15), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 20.9kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Epidermal growth factor receptor substrate 15 (EPS15), partial

Recombinant Human Epidermal growth factor receptor substrate 15 (EPS15), partial — Involved in cell growth regulation. Purity >90%.

SKU: BCRECP-000599 Categories: ,
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Product Specifications

Product SkuBCRECP-000599
Product DescriptionRecombinant Human Epidermal growth factor receptor substrate 15 (EPS15) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 657-798aa. [Accession | P42566].
Uniprot No.P42566
Gene NamesEPS15
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region657-798aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight20.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR.

Biological Context

Subcellular Location: Early endosome membrane (Peripheral membrane protein)
Tissue Specificity: Ubiquitously expressed
Disease Association: [A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein]

Product Specifications

Recombinant Human Epidermal growth factor receptor substrate 15 (EPS15), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 657-798aa, with N-terminal 6xHis-tagged tag, molecular weight 20.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2

Subcellular Location

Early endosome membrane (Peripheral membrane protein)

Disease Association

[A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein]

Tissue Specificity

Ubiquitously expressed

Subunit

(Microbial infection) Interacts with vaccinia virus protein A36

Gene: EPS15  |  Organism: Homo sapiens  |  Synonyms: Protein AF-1p
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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