Function
Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.
Biological Context
Subcellular Location: Secreted, extracellular space, extracellular matrix; Secreted
Tissue Specificity: Expressed in the inner limiting membrane and around blood vessels in the retina (at protein level). Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine
Disease Association: Glomerulopathy with fibronectin deposits 2 (GFND2) : Genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. [The disease is caused by variants affecting the gene represented in this entry] | Spondylometaphyseal dysplasia, corner fracture type (SMDCF) : An autosomal dominant form of spondylometaphyseal dysplasia, a group of short stature disorders distinguished by abnormalities in the vertebrae and the metaphyses of the tubular bones. SMDCF is characterized by flake-like, triangular, or curvilinear ossification centers at the edges of irregular metaphyses that simulate fractures. These corner fractures involve the distal tibia, the ulnar aspect of the distal radius, the proximal humerus, and the proximal femur. They represent irregular ossification at the growth plates and secondary ossification centers. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Fibronectin (FN1), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1270-1546aa&1721-2016aa, with Tag free tag, molecular weight 62.6 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
