Recombinant Human Fidgetin-like protein 1 (FIGNL1), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged, 37.1kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Fidgetin-like protein 1 (FIGNL1), partial

Recombinant Human Fidgetin-like protein 1 (FIGNL1), partial — ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR). Purity >85%.

SKU: BCRECP-000676 Category:
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Product Specifications

Product SkuBCRECP-000676
Product DescriptionRecombinant Human Fidgetin-like protein 1 (FIGNL1) Protein is expressed from E.coli with N-terminal 10xHis-tagged. It contains 374-674aa. [Accession | Q6PIW4].
Uniprot No.Q6PIW4
Gene NamesFIGNL1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region374-674aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight37.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases. Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA.

Biological Context

Subcellular Location: Chromosome; Nucleus; Cytoplasm; Cytoplasm, perinuclear region
Disease Association: [Ovarian dysgenesis. An autosomal recessive form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, dysgenic ovaries and hypergonadotropic hypogonadism as a result of streak gonads. The disease is caused by variants affecting the gene represented in this entry ]

Product Specifications

Recombinant Human Fidgetin-like protein 1 (FIGNL1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 374-674aa, with N-terminal 10xHis-tagged tag, molecular weight 37.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:23754376, PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA (By similarity). May regulate osteoblast proliferation and differentiation (By similarity)

Subcellular Location

Chromosome; Nucleus; Cytoplasm; Cytoplasm, perinuclear region

Disease Association

[Ovarian dysgenesis (PubMed:37740949). An autosomal recessive form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, dysgenic ovaries and hypergonadotropic hypogonadism as a result of streak gonads (PubMed:37740949). The disease is caused by variants affecting the gene represented in this entry (PubMed:37740949)]

Subunit

Hexamer; can dissociate RAD51 and DMC1 filments when assembled into a hexamer (PubMed:39636933, PubMed:41166468). Interacts with FIRRM; forming the FIGNL1-FIRRM complex, which regulates homologous recombination (PubMed:29608566, PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805). Interacts (via FRBD region) with RAD51; the interaction is direct and promotes dissociation of RAD51 nucleoprotein filaments (PubMed:23754376, PubMed:39636933, PubMed:41166468). Interacts (via FRBD region) with DMC1; the interaction is direct and promotes dissociation of DMC1 nucleoprotein filaments (By similarity). Interacts (via N-terminal one-half region) with SPIDR (via the C-terminal region); the interaction is direct (PubMed:23754376)

Gene: FIGNL1  |  Organism: Homo sapiens

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