Recombinant Human Fms-related tyrosine kinase 3 ligand protein (FLT3LG), partial (Active), Homo sapiens (Human), E.Coli, Tag-Free, 17.6 kDa, purity >>97% as determined by SDS-PAGE.
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Recombinant Human Fms-related tyrosine kinase 3 ligand protein (FLT3LG), partial (Active)

Recombinant Human Fms-related tyrosine kinase 3 ligand protein (FLT3LG), partial (Active) — Stimulates the proliferation of early hematopoietic cells by activating FLT3. Purity >97%.

SKU: BCACP-000882 Categories: , ,
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Product SKUBCACP-000882
Product DescriptionRecombinant Human Fms-related tyrosine kinase 3 ligand protein (FLT3LG) protein is expressed from E.Coli with Tag-Free. It contains 27-181aa. [Accession | P49771].
Uniprot No.P49771
Gene NamesFLT3LG
Purity>97% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region27-181aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight17.6 kDa
ActivityFully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 20 μg/ml, corresponding to a specific activity of >50 IU/mg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesFL; Flt 3 ligand; Flt 3L; Flt3 L; FLT3 LG; Flt3 ligand; Flt3L; FLT3L_HUMAN; Flt3lg; Fms related tyrosine kinase 3 ligand; Fms-related tyrosine kinase 3 ligand; SL cytokine

Function

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs).

Biological Context

Subcellular Location: Secreted
Disease Association: Immunodeficiency 125 (IMD125) : An autosomal recessive immunologic disorder characterized by failure to thrive and chronic diarrhea in infancy, and recurrent bacterial, viral, and fungal infections. Patients have severe human papilloma virus (HPV) infections with disseminated common warts, and the bone marrow is hypoplastic with low levels of CD34+ hematopoietic stem cells. Counts of B cells, monocytes, and dendritic cells are low in patients blood. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Fms-related tyrosine kinase 3 ligand protein (FLT3LG), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in E.Coli, covering amino acids 27-181aa, with Tag-Free tag, molecular weight 17.6 kDa, purity >97% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 20 μg/ml, corresponding to a specific activity of >50 IU/mg.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs)

Subcellular Location

Secreted

Disease Association

Immunodeficiency 125 (IMD125) : An autosomal recessive immunologic disorder characterized by failure to thrive and chronic diarrhea in infancy, and recurrent bacterial, viral, and fungal infections. Patients have severe human papilloma virus (HPV) infections with disseminated common warts, and the bone marrow is hypoplastic with low levels of CD34+ hematopoietic stem cells. Counts of B cells, monocytes, and dendritic cells are low in patients blood. [The disease may be caused by variants affecting the gene represented in this entry]

Subunit

Homodimer (isoform 2)

Gene: FLT3LG  |  Organism: Homo sapiens  |  Synonyms: SL cytokine
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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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