Recombinant Human Frizzled-2 (FZD2), partial, Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 46.9kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Frizzled-2 (FZD2), partial

Recombinant Human Frizzled-2 (FZD2), partial — (Microbial infection) Acts as a receptor for C. Purity >95%.

SKU: BCRECP-000710 Category:
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Product Specifications

Product SkuBCRECP-000710
Product DescriptionRecombinant Human Frizzled-2 (FZD2) Protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 24-190aa. [Accession | Q14332].
Uniprot No.Q14332
Gene NamesFZD2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region24-190aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight46.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling.

Biological Context

Subcellular Location: Membrane (Multi-pass membrane protein); Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver
Disease Association: Omodysplasia 2 (OMOD2) : A rare autosomal dominant skeletal dysplasia characterized by short humeri, radial head dislocation, short first metacarpals, facial dysmorphism and genitourinary anomalies. [The disease is caused by variants affecting the gene represented in this entry] | [Defects in FZD2 have been found in patients with Robinow syndrome-like features including short-limb dwarfism, broad thumbs and craniofacial abnormalities]

Product Specifications

Recombinant Human Frizzled-2 (FZD2), partial is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 24-190aa, with C-terminal hFc1-tagged tag, molecular weight 46.9kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium (PubMed:27680706, PubMed:29748286). TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling (PubMed:29748286)

Subcellular Location

Membrane (Multi-pass membrane protein); Cell membrane (Multi-pass membrane protein)

Disease Association

Omodysplasia 2 (OMOD2) : A rare autosomal dominant skeletal dysplasia characterized by short humeri, radial head dislocation, short first metacarpals, facial dysmorphism and genitourinary anomalies. [The disease is caused by variants affecting the gene represented in this entry] | [Defects in FZD2 have been found in patients with Robinow syndrome-like features including short-limb dwarfism, broad thumbs and craniofacial abnormalities]

Tissue Specificity

Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver

Subunit

(Microbial infection) Interacts with C.difficile toxin TcdB; frizzled receptors constitute the major host receptors for TcdB in the colonic epithelium

Gene: FZD2  |  Organism: Homo sapiens  |  Synonyms: FzE2
Key Publications

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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