Recombinant Human Glucose-6-phosphatase catalytic subunit 1 (G6PC1), partial, Homo sapiens (Human), Yeast, C-terminal 6xHis-tagged, 5.6kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Glucose-6-phosphatase catalytic subunit 1 (G6PC1), partial

Recombinant Human Glucose-6-phosphatase catalytic subunit 1 (G6PC1), partial — Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Purity >85%.

SKU: BCRECP-000712 Categories: ,
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Product Specifications

Product SkuBCRECP-000712
Product DescriptionRecombinant Human Glucose-6-phosphatase catalytic subunit 1 (G6PC1) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 82-117aa. [Accession | P35575].
Uniprot No.P35575
Gene NamesG6PC1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region82-117aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight5.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Multi-pass membrane protein)
Disease Association: Glycogen storage disease 1A (GSD1A) : A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Carbohydrate biosynthesis; gluconeogenesis

Product Specifications

Recombinant Human Glucose-6-phosphatase catalytic subunit 1 (G6PC1), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 82-117aa, with C-terminal 6xHis-tagged tag, molecular weight 5.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels

Subcellular Location

Endoplasmic reticulum membrane (Multi-pass membrane protein)

Disease Association

Glycogen storage disease 1A (GSD1A) : A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. [The disease is caused by variants affecting the gene represented in this entry]

Pathway

Carbohydrate biosynthesis; gluconeogenesis

Gene: G6PC1  |  Organism: Homo sapiens  |  Synonyms: Glucose-6-phosphatase; Glucose-6-phosphatase alpha
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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