Recombinant Human Growth hormone receptor (GHR), partial, Biotinylated (Active), Homo sapiens (Human), Mammalian cell, C-terminal mFc-Avi-tagged, 56.6kDa, purity >95% as determined by SDS-PAGE.
,

Recombinant Human Growth hormone receptor (GHR), partial, Biotinylated (Active)

Recombinant Human Growth hormone receptor (GHR), partial, Biotinylated (Active) — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >95%.

SKU: BCRECP-000742 Categories: ,
Online Inquiry →

Product Specifications

Product SkuBCRECP-000742
Product DescriptionRecombinant Human Growth hormone receptor (GHR) Protein is expressed from Mammalian cell with C-terminal mFc-Avi-tagged. It contains 27-264aa. [Accession | P10912].
Uniprot No.P10912
Gene NamesGHR
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region27-264aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal mFc-Avi-tagged
Molecular weight56.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Up-regulates the production of the soluble Growth hormone-binding protein form (GHBP) and acts as a negative inhibitor of growth hormone signaling.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Predominantly expressed in kidney, bladder, adrenal gland and brain stem. Highly expressed in placental villi
Disease Association: Laron syndrome (LARS) : A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. [The disease is caused by variants affecting the gene represented in this entry] | Growth hormone insensitivity, partial (GHIP) : A disease characterized by partial resistance to growth hormone resulting in short stature. Short stature is defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, healthy, genetically relevant population. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Growth hormone receptor (GHR), partial, Biotinylated (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 27-264aa, with C-terminal mFc-Avi-tagged tag, molecular weight 56.6kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Up-regulates the production of the soluble Growth hormone-binding protein form (GHBP) and acts as a negative inhibitor of growth hormone signaling

Subcellular Location

Secreted

Disease Association

Laron syndrome (LARS) : A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. [The disease is caused by variants affecting the gene represented in this entry] | Growth hormone insensitivity, partial (GHIP) : A disease characterized by partial resistance to growth hormone resulting in short stature. Short stature is defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, healthy, genetically relevant population. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Predominantly expressed in kidney, bladder, adrenal gland and brain stem (PubMed:1569971). Highly expressed in placental villi (PubMed:1569971, PubMed:8360189)

Subunit

On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain

Gene: GHR  |  Organism: Homo sapiens  |  Synonyms: Somatotropin receptor
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

Shopping Cart
Scroll to Top