Recombinant Human Heat shock protein 75 kDa, mitochondrial (TRAP1), partial, Homo sapiens (Human), E.coli, N-terminal GST-tagged, 54.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Heat shock protein 75 kDa, mitochondrial (TRAP1), partial

Recombinant Human Heat shock protein 75 kDa, mitochondrial (TRAP1), partial — Chaperone that expresses an ATPase activity. Purity >90%.

SKU: BCRECP-001839 Category:
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Product Specifications

Product SkuBCRECP-001839
Product DescriptionRecombinant Human Heat shock protein 75 kDa, mitochondrial (TRAP1) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 60-308aa. [Accession | Q12931].
Uniprot No.Q12931
Gene NamesTRAP1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region60-308aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight54.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis.

Biological Context

Subcellular Location: Mitochondrion; Mitochondrion inner membrane; Mitochondrion matrix
Tissue Specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors

Product Specifications

Recombinant Human Heat shock protein 75 kDa, mitochondrial (TRAP1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 60-308aa, with N-terminal GST-tagged tag, molecular weight 54.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA

Subcellular Location

Mitochondrion; Mitochondrion inner membrane; Mitochondrion matrix

Tissue Specificity

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors

Subunit

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA

Gene: TRAP1  |  Organism: Homo sapiens  |  Synonyms: Heat shock protein family C member 5; TNFR-associated protein 1; Tumor necrosis factor type 1 receptor-associated protein
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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