Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 74.9 kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active)

Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) — Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Purity >90%.

SKU: BCACP-000128 Category:
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Product SKUBCACP-000128
Product DescriptionRecombinant Human Heat-stable enterotoxin receptor (GUCY2C) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 24-430aa. [Accession | P25092].
Uniprot No.P25092
Gene NamesGUCY2C
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region24-430aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight74.9 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized N ) at 2 μg/ml can bind N Mouse Monoclonal Antibody, the EC50 of N Mouse Monoclonal Antibody is 11.40-19.77 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized N ) at 2 μg/ml can bind N Recombinant Antibody, the EC50 of N Recombinant Antibody is 63.78-113.6 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(STA receptor)(hSTAR)(Guanylyl cyclase C)(GC-C)(Intestinal guanylate cyclase)

Function

Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Endoplasmic reticulum membrane (Single-pass type I membrane protein)
Disease Association: Diarrhea 6 (DIAR6) : A relatively mild, early-onset chronic diarrhea that may be associated with increased susceptibility to inflammatory bowel disease, small bowel obstruction, and esophagitis. [The disease is caused by variants affecting the gene represented in this entry] | Meconium ileus (MECIL) : A condition characterized by intestinal obstruction due to inspissated meconium in the distal ileum and cecum, which develops in utero and presents shortly after birth as a failure to pass meconium. Meconium ileus is a known clinical manifestation of cystic fibrosis. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 24-430aa, with C-terminal hFc1-tagged tag, molecular weight 74.9 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized N ) at 2 μg/ml can bind N Mouse Monoclonal Antibody, the EC50 of N Mouse Monoclonal Antibody is 11.40-19.77 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized N ) at 2 μg/ml can bind N Recombinant Antibody, the EC50 of N Recombinant Antibody is 63.78-113.6 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:11950846, PubMed:1718270, PubMed:22436048, PubMed:22521417, PubMed:23269669). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1680854, PubMed:1718270). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed:8381596)

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Endoplasmic reticulum membrane (Single-pass type I membrane protein)

Disease Association

Diarrhea 6 (DIAR6) : A relatively mild, early-onset chronic diarrhea that may be associated with increased susceptibility to inflammatory bowel disease, small bowel obstruction, and esophagitis. [The disease is caused by variants affecting the gene represented in this entry] | Meconium ileus (MECIL) : A condition characterized by intestinal obstruction due to inspissated meconium in the distal ileum and cecum, which develops in utero and presents shortly after birth as a failure to pass meconium. Meconium ileus is a known clinical manifestation of cystic fibrosis. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Homotrimer (PubMed:11123935). Interacts via its C-terminal region with NHERF4 (PubMed:11950846). Interacts with the lectin chaperone VIP36 (PubMed:23269669)

Gene: GUCY2C  |  Organism: Homo sapiens  |  Synonyms: Heat-stable enterotoxin receptor; Intestinal guanylate cyclase
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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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