Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active), Homo sapiens (Human), Mammalian cell, N-terminal 10xHis-tagged, 49.6kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active)

Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) — Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Purity >95%.

SKU: BCRECP-000797 Category:
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Product Specifications

Product SkuBCRECP-000797
Product DescriptionRecombinant Human Heat-stable enterotoxin receptor (GUCY2C) Protein is expressed from Mammalian cell with N-terminal 10xHis-tagged. It contains 24-430aa. [Accession | P25092].
Uniprot No.P25092
Gene NamesGUCY2C
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region24-430aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight49.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMetabolism

Function

Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Endoplasmic reticulum membrane (Single-pass type I membrane protein)
Disease Association: Diarrhea 6 (DIAR6) : A relatively mild, early-onset chronic diarrhea that may be associated with increased susceptibility to inflammatory bowel disease, small bowel obstruction, and esophagitis. [The disease is caused by variants affecting the gene represented in this entry] | Meconium ileus (MECIL) : A condition characterized by intestinal obstruction due to inspissated meconium in the distal ileum and cecum, which develops in utero and presents shortly after birth as a failure to pass meconium. Meconium ileus is a known clinical manifestation of cystic fibrosis. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 24-430aa, with N-terminal 10xHis-tagged tag, molecular weight 49.6kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:11950846, PubMed:1718270, PubMed:22436048, PubMed:22521417, PubMed:23269669). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1680854, PubMed:1718270). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed:8381596)

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Endoplasmic reticulum membrane (Single-pass type I membrane protein)

Disease Association

Diarrhea 6 (DIAR6) : A relatively mild, early-onset chronic diarrhea that may be associated with increased susceptibility to inflammatory bowel disease, small bowel obstruction, and esophagitis. [The disease is caused by variants affecting the gene represented in this entry] | Meconium ileus (MECIL) : A condition characterized by intestinal obstruction due to inspissated meconium in the distal ileum and cecum, which develops in utero and presents shortly after birth as a failure to pass meconium. Meconium ileus is a known clinical manifestation of cystic fibrosis. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Homotrimer (PubMed:11123935). Interacts via its C-terminal region with NHERF4 (PubMed:11950846). Interacts with the lectin chaperone VIP36 (PubMed:23269669)

Gene: GUCY2C  |  Organism: Homo sapiens  |  Synonyms: Heat-stable enterotoxin receptor; Intestinal guanylate cyclase
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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