Recombinant Human herpesvirus 1 ICP47 protein (US12), Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1), E.coli, N-terminal 10xHis-tagged, 13.3kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human herpesvirus 1 ICP47 protein (US12)

Recombinant Human herpesvirus 1 ICP47 protein (US12) — Plays a role in the inhibition of host immune response. Purity >85%.

SKU: BCRECP-004690 Categories: ,
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Product Specifications

Product SkuBCRECP-004690
Product DescriptionRecombinant Human herpesvirus 1 ICP47 protein (US12) Protein is expressed from E.coli with N-terminal 10xHis-tagged. It contains 1-88aa. [Accession | P03170].
Uniprot No.P03170
Gene NamesUS12
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-88aa
SpeciesHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Tag InfoN-terminal 10xHis-tagged
Molecular weight13.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation.

Biological Context

Subcellular Location: Host cytoplasm; Host nucleus

Product Specifications

Recombinant Human herpesvirus 1 ICP47 protein (US12) is a recombinant protein from Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1), expressed in E.coli, covering amino acids 1-88aa, with N-terminal 10xHis-tagged tag, molecular weight 13.3kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes

Subcellular Location

Host cytoplasm; Host nucleus

Subunit

Interacts with host TAP1 and TAP2; these interactions inhibit the loading of peptides onto MHC class I molecules

Gene: US12  |  Organism: Human herpesvirus 1 (strain 17)  |  Synonyms: Immediate-early protein IE12; Immediate-early-5; Infected cell protein 47; US12 protein; Vmw12
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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