Recombinant Human herpesvirus 2 Envelope glycoprotein L (gL), Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2), E.coli, C-terminal 6xHis-tagged, 30.5kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human herpesvirus 2 Envelope glycoprotein L (gL)

Recombinant Human herpesvirus 2 Envelope glycoprotein L (gL) — The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Purity >85%.

SKU: BCRECP-002861 Categories: ,
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Product Specifications

Product SkuBCRECP-002861
Product DescriptionRecombinant Human herpesvirus 2 Envelope glycoprotein L (gL) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 17-224aa. [Accession | P28278].
Uniprot No.P28278
Gene NamesgL
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region17-224aa
SpeciesHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Tag InfoC-terminal 6xHis-tagged
Molecular weight30.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.

Biological Context

Subcellular Location: Virion membrane (Peripheral membrane protein); Host cell membrane (Peripheral membrane protein); Host Golgi apparatus, host trans-Golgi network

Product Specifications

Recombinant Human herpesvirus 2 Envelope glycoprotein L (gL) is a recombinant protein from Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2), expressed in E.coli, covering amino acids 17-224aa, with C-terminal 6xHis-tagged tag, molecular weight 30.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH

Subcellular Location

Virion membrane (Peripheral membrane protein); Host cell membrane (Peripheral membrane protein); Host Golgi apparatus, host trans-Golgi network

Subunit

Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion

Gene: gL  |  Organism: Human herpesvirus 2 (strain HG52)

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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