Recombinant Human herpesvirus 2 Envelope glycoprotein L (gL), Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2), E.coli, C-terminal 6xHis-tagged, 30.5kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human herpesvirus 2 Envelope glycoprotein L (gL)

Recombinant Human herpesvirus 2 Envelope glycoprotein L (gL) — The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Purity >85%.

SKU: BCRECP-002861 Categories: ,
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Product Specifications

Product SkuBCRECP-002861
Product DescriptionRecombinant Human herpesvirus 2 Envelope glycoprotein L (gL) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 17-224aa. [Accession | P28278].
Uniprot No.P28278
Gene NamesgL
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region17-224aa
SpeciesHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Tag InfoC-terminal 6xHis-tagged
Molecular weight30.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.

Biological Context

Subcellular Location: Virion membrane (Peripheral membrane protein); Host cell membrane (Peripheral membrane protein); Host Golgi apparatus, host trans-Golgi network

Product Specifications

Recombinant Human herpesvirus 2 Envelope glycoprotein L (gL) is a recombinant protein from Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2), expressed in E.coli, covering amino acids 17-224aa, with C-terminal 6xHis-tagged tag, molecular weight 30.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH

Subcellular Location

Virion membrane (Peripheral membrane protein); Host cell membrane (Peripheral membrane protein); Host Golgi apparatus, host trans-Golgi network

Subunit

Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion

Gene: gL  |  Organism: Human herpesvirus 2 (strain HG52)

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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