Recombinant Human IL1RL1 / ST2 Protein, HEK293 Cells, C-His, 36.5 kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human IL1RL1 / ST2 Protein

Recombinant Human IL1RL1 / ST2 Protein — recombinant protein, expressed in HEK293 Cells. Purity >85%.

SKU: BCRETP-000035 Category:
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Product Specifications

Product SkuBCRETP-000035
Product DescriptionRecombinant Human IL1RL1 / ST2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains 1-328aa. [Accession | Q01638].
Uniprot No.Q01638
SynonymsDER4;FIT-1;IL1RL1;IL33R;IL‑1 R4;ST2;ST2L;ST2V;T1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemHEK293 Cells
Expression Region1-328aa
Tag InfoC-His
Molecular weight36.5 kDa
EndotoxinLess than 1.0 EU/μg as determined by LAL method.

Function

Inhibits IL-33 signaling.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver

Product Specifications

Recombinant Human IL1RL1 / ST2 Protein is a recombinant protein, expressed in HEK293 Cells, covering amino acids 1-328aa, with C-His tag, molecular weight 36.5 kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: PBS pH 7.4, 0.01% SKL, 5% Trehalose, 1% Mannitol

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Inhibits IL-33 signaling

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Tissue Specificity

Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver

Subunit

Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88. Interacts with TMED1 (PubMed:23319592)

Gene: IL1RL1  |  Organism: Homo sapiens  |  Synonyms: Protein ST2
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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