Recombinant Human Inorganic pyrophosphatase 2, mitochondrial (PPA2), Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 41.6kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Inorganic pyrophosphatase 2, mitochondrial (PPA2)

Recombinant Human Inorganic pyrophosphatase 2, mitochondrial (PPA2) — Hydrolyzes inorganic pyrophosphate. Purity >85%.

SKU: BCRECP-001423 Categories: ,
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Product Specifications

Product SkuBCRECP-001423
Product DescriptionRecombinant Human Inorganic pyrophosphatase 2, mitochondrial (PPA2) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 33-334aa. [Accession | Q9H2U2].
Uniprot No.Q9H2U2
Gene NamesPPA2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region33-334aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight41.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function.

Biological Context

Subcellular Location: Mitochondrion
Tissue Specificity: Detected in brain, gastric carcinoma, lung, ovary, skeletal muscle, umbilical cord blood and a cell line derived from kidney proximal tubule epithelium
Disease Association: Sudden cardiac failure, alcohol-induced (SCFAI) : An autosomal recessive disease characterized by sudden death due to unexpected cardiac arrest following ingestion of small amounts of alcohol. [The disease is caused by variants affecting the gene represented in this entry] | Sudden cardiac failure, infantile (SCFI) : A disease characterized by sudden death within the first 2 years of life due to unexpected cardiac arrest. Some patients manifest hypertrophic cardiomyopathy, lipid accumulation in myocardium, degeneration of mitochondrial cristae, metabolic acidosis, and elevated plasma lactate levels. SCFI transmission pattern is consistent with autosomal recessive inheritance. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Inorganic pyrophosphatase 2, mitochondrial (PPA2) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 33-334aa, with C-terminal 6xHis-tagged tag, molecular weight 41.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598)

Subcellular Location

Mitochondrion

Disease Association

Sudden cardiac failure, alcohol-induced (SCFAI) : An autosomal recessive disease characterized by sudden death due to unexpected cardiac arrest following ingestion of small amounts of alcohol. [The disease is caused by variants affecting the gene represented in this entry] | Sudden cardiac failure, infantile (SCFI) : A disease characterized by sudden death within the first 2 years of life due to unexpected cardiac arrest. Some patients manifest hypertrophic cardiomyopathy, lipid accumulation in myocardium, degeneration of mitochondrial cristae, metabolic acidosis, and elevated plasma lactate levels. SCFI transmission pattern is consistent with autosomal recessive inheritance. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Detected in brain, gastric carcinoma, lung, ovary, skeletal muscle, umbilical cord blood and a cell line derived from kidney proximal tubule epithelium

Subunit

Homodimer

Gene: PPA2  |  Organism: Homo sapiens  |  Synonyms: Pyrophosphatase SID6-306; Pyrophosphate phospho-hydrolase 2
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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