Recombinant Human Inorganic pyrophosphatase 2, mitochondrial (PPA2), Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 41.6kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Inorganic pyrophosphatase 2, mitochondrial (PPA2)

Recombinant Human Inorganic pyrophosphatase 2, mitochondrial (PPA2) — Hydrolyzes inorganic pyrophosphate. Purity >85%.

SKU: BCRECP-001423 Categories: ,
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Product Specifications

Product SkuBCRECP-001423
Product DescriptionRecombinant Human Inorganic pyrophosphatase 2, mitochondrial (PPA2) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 33-334aa. [Accession | Q9H2U2].
Uniprot No.Q9H2U2
Gene NamesPPA2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region33-334aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight41.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function.

Biological Context

Subcellular Location: Mitochondrion
Tissue Specificity: Detected in brain, gastric carcinoma, lung, ovary, skeletal muscle, umbilical cord blood and a cell line derived from kidney proximal tubule epithelium
Disease Association: Sudden cardiac failure, alcohol-induced (SCFAI) : An autosomal recessive disease characterized by sudden death due to unexpected cardiac arrest following ingestion of small amounts of alcohol. [The disease is caused by variants affecting the gene represented in this entry] | Sudden cardiac failure, infantile (SCFI) : A disease characterized by sudden death within the first 2 years of life due to unexpected cardiac arrest. Some patients manifest hypertrophic cardiomyopathy, lipid accumulation in myocardium, degeneration of mitochondrial cristae, metabolic acidosis, and elevated plasma lactate levels. SCFI transmission pattern is consistent with autosomal recessive inheritance. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Inorganic pyrophosphatase 2, mitochondrial (PPA2) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 33-334aa, with C-terminal 6xHis-tagged tag, molecular weight 41.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598)

Subcellular Location

Mitochondrion

Disease Association

Sudden cardiac failure, alcohol-induced (SCFAI) : An autosomal recessive disease characterized by sudden death due to unexpected cardiac arrest following ingestion of small amounts of alcohol. [The disease is caused by variants affecting the gene represented in this entry] | Sudden cardiac failure, infantile (SCFI) : A disease characterized by sudden death within the first 2 years of life due to unexpected cardiac arrest. Some patients manifest hypertrophic cardiomyopathy, lipid accumulation in myocardium, degeneration of mitochondrial cristae, metabolic acidosis, and elevated plasma lactate levels. SCFI transmission pattern is consistent with autosomal recessive inheritance. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Detected in brain, gastric carcinoma, lung, ovary, skeletal muscle, umbilical cord blood and a cell line derived from kidney proximal tubule epithelium

Subunit

Homodimer

Gene: PPA2  |  Organism: Homo sapiens  |  Synonyms: Pyrophosphatase SID6-306; Pyrophosphate phospho-hydrolase 2
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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