Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial, Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 26.2kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial

Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >95%.

SKU: BCRECP-000902 Categories: ,
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Product Specifications

Product SkuBCRECP-000902
Product DescriptionRecombinant Human Interferon alpha/beta receptor 2 (IFNAR2) Protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 27-243aa. [Accession | P48551].
Uniprot No.P48551
Gene NamesIFNAR2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region27-243aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight26.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Potent inhibitor of type I IFN receptor activity.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines
Disease Association: Immunodeficiency 45 (IMD45) : An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 27-243aa, with C-terminal 10xHis-tagged tag, molecular weight 26.2kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Potent inhibitor of type I IFN receptor activity

Subcellular Location

Secreted

Disease Association

Immunodeficiency 45 (IMD45) : An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Isoform 3 is detected in the urine (at protein level) (PubMed:7759950, PubMed:8181059). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines

Subunit

Heterodimer with IFNAR1; forming the receptor for type I interferon (PubMed:10049744, PubMed:21854986, PubMed:24075985, PubMed:7665574, PubMed:8181059). Interacts with JAK1 (PubMed:7759950, PubMed:8181059). Interacts with the transcriptional factors STAT1 and STAT2 (PubMed:28165510, PubMed:9121453). Interacts with USP18; indirectly via STAT2, it negatively regulates the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and therefore type I interferon signaling (PubMed:28165510)

Gene: IFNAR2  |  Organism: Homo sapiens  |  Synonyms: Interferon alpha binding protein; Type I interferon receptor 2
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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