Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial, Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 53.7kDa, purity >95% as determined by SDS-PAGE.
,

Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial

Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >95%.

SKU: BCRECP-000901 Categories: ,
Online Inquiry →

Product Specifications

Product SkuBCRECP-000901
Product DescriptionRecombinant Human Interferon alpha/beta receptor 2 (IFNAR2) Protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 27-243aa. [Accession | P48551].
Uniprot No.P48551
Gene NamesIFNAR2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region27-243aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight53.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Potent inhibitor of type I IFN receptor activity.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines
Disease Association: Immunodeficiency 45 (IMD45) : An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 27-243aa, with C-terminal hFc1-tagged tag, molecular weight 53.7kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Potent inhibitor of type I IFN receptor activity

Subcellular Location

Secreted

Disease Association

Immunodeficiency 45 (IMD45) : An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Isoform 3 is detected in the urine (at protein level) (PubMed:7759950, PubMed:8181059). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines

Subunit

Heterodimer with IFNAR1; forming the receptor for type I interferon (PubMed:10049744, PubMed:21854986, PubMed:24075985, PubMed:7665574, PubMed:8181059). Interacts with JAK1 (PubMed:7759950, PubMed:8181059). Interacts with the transcriptional factors STAT1 and STAT2 (PubMed:28165510, PubMed:9121453). Interacts with USP18; indirectly via STAT2, it negatively regulates the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and therefore type I interferon signaling (PubMed:28165510)

Gene: IFNAR2  |  Organism: Homo sapiens  |  Synonyms: Interferon alpha binding protein; Type I interferon receptor 2
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

Shopping Cart
Scroll to Top