Recombinant Human Interferon alpha-inducible protein 6 (IFI6), Homo sapiens (Human), E.coli, N-terminal 6xHis-B2M-tagged, 24.4kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Interferon alpha-inducible protein 6 (IFI6)

Recombinant Human Interferon alpha-inducible protein 6 (IFI6) — Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses. Purity >90%.

SKU: BCRECP-000888 Categories: ,
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Product Specifications

Product SkuBCRECP-000888
Product DescriptionRecombinant Human Interferon alpha-inducible protein 6 (IFI6) Protein is expressed from E.coli with N-terminal 6xHis-B2M-tagged. It contains 24-130aa. [Accession | P09912].
Uniprot No.P09912
Gene NamesIFI6
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region24-130aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-B2M-tagged
Molecular weight24.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses. Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells.

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Multi-pass membrane protein); Mitochondrion inner membrane (Multi-pass membrane protein)

Product Specifications

Recombinant Human Interferon alpha-inducible protein 6 (IFI6) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 24-130aa, with N-terminal 6xHis-B2M-tagged tag, molecular weight 24.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses (PubMed:31142663). Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication (PubMed:30224801). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells (PubMed:25757571). Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression (PubMed:33868257). Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746). Modulates innate immune response mediated by RIGI by preventing its activation (PubMed:36793726)

Subcellular Location

Endoplasmic reticulum membrane (Multi-pass membrane protein); Mitochondrion inner membrane (Multi-pass membrane protein)

Subunit

Interacts with CIB1; the interaction is direct. Interacts with the chaperone BIP/HSPA5 (PubMed:30224801). Interacts with RIGI (PubMed:36793726)

Gene: IFI6  |  Organism: Homo sapiens  |  Synonyms: Interferon-induced protein 6-16
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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