Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 27.7kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial

Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial — The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. Purity >85%.

SKU: BCRECP-000911 Categories: ,
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Product Specifications

Product SkuBCRECP-000911
Product DescriptionRecombinant Human Interferon lambda receptor 1 (IFNLR1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 21-228aa. [Accession | Q8IU57].
Uniprot No.Q8IU57
Gene NamesIFNLR1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region21-228aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight27.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein)
Tissue Specificity: Widely expressed

Product Specifications

Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 21-228aa, with N-terminal 6xHis-tagged tag, molecular weight 27.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium

Subcellular Location

Membrane (Single-pass type I membrane protein)

Tissue Specificity

Widely expressed

Subunit

Heterodimer with IL10RB

Gene: IFNLR1  |  Organism: Homo sapiens  |  Synonyms: Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; Interleukin-28 receptor subunit alpha; Likely interleukin or cytokine receptor 2
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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