Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial, Homo sapiens (Human), E.coli, Tag-Free, 23.6kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial

Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial — The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. Purity >85%.

SKU: BCRECP-000910 Categories: ,
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Product Specifications

Product SkuBCRECP-000910
Product DescriptionRecombinant Human Interferon lambda receptor 1 (IFNLR1) Protein is expressed from E.coli with Tag-Free. It contains 21-228aa. [Accession | Q8IU57].
Uniprot No.Q8IU57
Gene NamesIFNLR1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region21-228aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight23.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein)
Tissue Specificity: Widely expressed

Product Specifications

Recombinant Human Interferon lambda receptor 1 (IFNLR1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 21-228aa, with Tag-Free tag, molecular weight 23.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium

Subcellular Location

Membrane (Single-pass type I membrane protein)

Tissue Specificity

Widely expressed

Subunit

Heterodimer with IL10RB

Gene: IFNLR1  |  Organism: Homo sapiens  |  Synonyms: Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; Interleukin-28 receptor subunit alpha; Likely interleukin or cytokine receptor 2
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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