Recombinant Human Interleukin-1 receptor type 2 (IL1R2), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 65.3 kDa, purity >95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.
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Recombinant Human Interleukin-1 receptor type 2 (IL1R2), partial (Active)

Recombinant Human Interleukin-1 receptor type 2 (IL1R2), partial (Active) — Non-signaling receptor for IL1A, IL1B and IL1RN. Purity >95%.

SKU: BCACP-000464 Categories: ,
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Product SKUBCACP-000464
Product DescriptionRecombinant Human Interleukin-1 receptor type 2 (IL1R2) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 14-343aa. [Accession | P27930].
Uniprot No.P27930
Gene NamesIL1R2
PurityGreater than 95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region14-343aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight65.3 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Mouse cldn6 at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody. The EC50 is 4.027-6.270 ng/mL.The VLPs is negative control.;Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6 at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody. The EC50 is 7.349-12.12 ng/mL.The VLPs is negative control.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInterleukin-1 receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta (IL-1R-beta); Interleukin-1 receptor type II; Interleukin-1 receptor type 2, membrane form (mIL-1R2; mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2; sIL-1RII); CD121b; IL1R2; IL1RB

Function

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1.

Product Specifications

Recombinant Human Interleukin-1 receptor type 2 (IL1R2), partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 14-343aa, with C-terminal hFc1-tagged tag, molecular weight 65.3 kDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

Gene: IL1R2  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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