Recombinant Human interleukin-16 protein (IL16), partial (Active), Homo sapiens (Human), E.Coli, Tag-Free, 13.4 kDa, purity >>95% as determined by SDS-PAGE.
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Recombinant Human interleukin-16 protein (IL16), partial (Active)

Recombinant Human interleukin-16 protein (IL16), partial (Active) — Isoform 3 is involved in cell cycle progression in T-cells. Purity >95%.

SKU: BCACP-000668 Categories: ,
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Product SKUBCACP-000668
Product DescriptionRecombinant Human interleukin-16 protein (IL16) protein is expressed from E.Coli with Tag-Free. It contains 1203-1332aa. [Accession | Q14005].
Uniprot No.Q14005
Gene NamesIL16
Purity>95% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region1203-1332aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight13.4 kDa
ActivityFully biologically active when compared to standard. The ED50 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0 μg/ml, corresponding to a specific activity of >1000 IU/mg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesHGNC:5980; HsT19289; IL-16; IL16; IL16_HUMAN; Interleukin 16 precursor; Interleukin-16; LCF; Lymphocyte chemoattractant factor; Neuronal interleukin 16; NIL16; prIL 16; PrIL16 ; Prointerleukin 16

Function

Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Biological Context

Subcellular Location: Cytoplasm; Nucleus
Tissue Specificity: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation

Product Specifications

Recombinant Human interleukin-16 protein (IL16), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in E.Coli, covering amino acids 1203-1332aa, with Tag-Free tag, molecular weight 13.4 kDa, purity >95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0 μg/ml, corresponding to a specific activity of >1000 IU/mg.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells

Subcellular Location

Cytoplasm; Nucleus

Tissue Specificity

Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation

Subunit

(Microbial infection) Isoform 3 interacts with HTLV-1 tax

Gene: IL16  |  Organism: Homo sapiens
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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