Recombinant Mouse Pro-interleukin-16 [Cleaved into: Interleukin-16 protein (Il16), Mus musculus (Mouse), E.Coli, Tag-Free, 12.2 kDa, purity >>98% as determined by SDS-PAGE.
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Recombinant Mouse Pro-interleukin-16 [Cleaved into: Interleukin-16 protein (Il16)

Recombinant Mouse Pro-interleukin-16 [Cleaved into: Interleukin-16 protein (Il16) — Isoform 2 is involved in cell cycle progression in T-cells. Purity >98%.

SKU: BCACP-000722 Categories: ,
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Product SKUBCACP-000722
Product DescriptionRecombinant Mouse Pro-interleukin-16 [Cleaved into: Interleukin-16 protein (Il16) protein is expressed from E.Coli with Tag-Free. It contains 1205-1322aa. [Accession | O54824].
Uniprot No.O54824
Gene NamesIl16
Purity>98% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region1205-1322aa
SpeciesMus musculus (Mouse)
Tag InfoTag-Free
Molecular weight12.2 kDa
ActivityFully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesIl16; Pro-interleukin-16 [Cleaved into: Interleukin-16; IL-16; Lymphocyte chemoattractant factor; LCF)]

Function

Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Biological Context

Subcellular Location: Cytoplasm; Nucleus
Tissue Specificity: Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung

Product Specifications

Recombinant Mouse Pro-interleukin-16 [Cleaved into: Interleukin-16 protein (Il16) is a recombinant protein from Mus musculus (Mouse), expressed in E.Coli, covering amino acids 1205-1322aa, with Tag-Free tag, molecular weight 12.2 kDa, purity >98% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells

Subcellular Location

Cytoplasm; Nucleus

Tissue Specificity

Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung

Subunit

Homotetramer (Probable). Isoform 2 interacts with GRIN2A. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C. Isoform 2 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GABPB1. Isoform 2 interacts (via PDZ 3 domain) with HDAC3 (By similarity)

Gene: Il16  |  Organism: Mus musculus
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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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