Recombinant Human Interleukin-21 receptor (IL21R), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 26.7 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Interleukin-21 receptor (IL21R), partial (Active)

Recombinant Human Interleukin-21 receptor (IL21R), partial (Active) — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >95%.

SKU: BCACP-000603 Categories: ,
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Product SKUBCACP-000603
Product DescriptionRecombinant Human Interleukin-21 receptor (IL21R) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 20-236aa. [Accession | Q9HBE5].
Uniprot No.Q9HBE5
Gene NamesIL21R
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region20-236aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight26.7 kDa
ActivityMeasured by its ability to cleave the fluorogenic peptide substrate, MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys(DNP)NH2. The specific activity is >50 pmol/min/µg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInterleukin-21 receptor; IL-21 receptor; IL-21R; Novel interleukin receptor; CD antigen CD360

Function

This is a receptor for interleukin-21.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein)
Tissue Specificity: Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen
Disease Association: Immunodeficiency 56 (IMD56) : An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens. [The disease is caused by variants affecting the gene represented in this entry] | [Chromosomal aberrations involving IL21R is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;16)(q27;p11), with BCL6]

Product Specifications

Recombinant Human Interleukin-21 receptor (IL21R), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 20-236aa, with C-terminal 10xHis-tagged tag, molecular weight 26.7 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate, MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys(DNP)NH2. The specific activity is >50 pmol/min/µg.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

This is a receptor for interleukin-21

Subcellular Location

Membrane (Single-pass type I membrane protein)

Disease Association

Immunodeficiency 56 (IMD56) : An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens. [The disease is caused by variants affecting the gene represented in this entry] | [Chromosomal aberrations involving IL21R is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;16)(q27;p11), with BCL6]

Tissue Specificity

Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen

Subunit

Heterodimer with the common gamma subunit. Associates with JAK1

Gene: IL21R  |  Organism: Homo sapiens  |  Synonyms: Novel interleukin receptor
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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