Recombinant Human Interleukin-22 (IL22), partial (Active), Homo sapiens (Human), E.coli, Tag-Free, 16.9 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Interleukin-22 (IL22), partial (Active)

Recombinant Human Interleukin-22 (IL22), partial (Active) — Cytokine that plays a critical role in modulating tissue responses during inflammation. Purity >95%.

SKU: BCACP-001009 Categories: ,
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Product SKUBCACP-001009
Product DescriptionRecombinant Human Interleukin-22 (IL22) protein is expressed from E.coli with Tag-Free. It contains 34-179aa. [Accession | Q9GZX6].
Uniprot No.Q9GZX6
Gene NamesIL22
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region34-179aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight16.9 kDa
ActivityThe specific activity of recombinant Human IL-2 as measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells is ≥1×107 IU/mg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCytokine Zcyto18; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; IL-10-related T-cell-derived-inducible factor; IL-22; IL-TIF; IL21; Il22; IL22_HUMAN; ILD110; ILTIF; Interleukin 10 related T cell derived inducible factor; interleukin 21; Interleukin 22; Interleukin-22; MGC79382; MGC79384; TIFa; TIFIL 23; TIFIL23; UNQ3099/PRO10096; zcyto18

Function

Cytokine that plays a critical role in modulating tissue responses during inflammation. Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage.

Product Specifications

Recombinant Human Interleukin-22 (IL22), partial (Active) — Cytokine that plays a critical role in modulating tissue responses during inflammation. Purity >95%. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: The specific activity of recombinant Human IL-2 as measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells is ≥1×107 IU/mg.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:17204547). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:17204547). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB (PubMed:10875937, PubMed:18599299). Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways (PubMed:25793261, PubMed:31311100). Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (By similarity). Promotes epithelial cell spreading (By similarity)

Subcellular Location

Secreted

Gene: IL22  |  Organism: Homo sapiens  |  Synonyms: Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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