Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 60.5 kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial (Active)

Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial (Active) — (Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein. Purity >90%.

SKU: BCACP-000427 Category:
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Product SKUBCACP-000427
Product DescriptionRecombinant Human Leucine-rich repeat-containing protein 15 (LRRC15) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 22-538aa. [Accession | Q8TF66].
Uniprot No.Q8TF66
Gene NamesLRRC15
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region22-538aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight60.5 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 at 2 μg/mL can bind Anti-TNFSF15 recombinant antibody . The EC50 is 0.7563-0.8726 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesLeucine-rich repeat-containing protein 15; Leucine-rich repeat protein induced by beta-amyloid homolog (hLib); LRRC15; LIB

Function

(Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein. Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells.

Product Specifications

Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial (Active) — (Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein. Purity >90%. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 at 2 μg/mL can bind Anti-TNFSF15 recombinant antibody . The EC50 is 0.7563-0.8726 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein (PubMed:36228039, PubMed:36735681, PubMed:36757924). Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells (PubMed:36228039, PubMed:36757924)

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Tissue Specificity

Expressed in brain and placenta (PubMed:11785964). Expressed in lung fibroblasts (PubMed:36228039, PubMed:36757924). Expressed in chodrocytes (PubMed:34702854)

Subunit

(Microbial infection) Interacts with human coronavirus SARS-CoV-2 spike protein (via RBD domain); the interaction is direct

Gene: LRRC15  |  Organism: Homo sapiens  |  Synonyms: Leucine-rich repeat protein induced by beta-amyloid homolog
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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