Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 60.5 kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial (Active)

Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial (Active) — (Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein. Purity >90%.

SKU: BCACP-000427 Category:
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Product SKUBCACP-000427
Product DescriptionRecombinant Human Leucine-rich repeat-containing protein 15 (LRRC15) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 22-538aa. [Accession | Q8TF66].
Uniprot No.Q8TF66
Gene NamesLRRC15
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region22-538aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight60.5 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 at 2 μg/mL can bind Anti-TNFSF15 recombinant antibody . The EC50 is 0.7563-0.8726 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesLeucine-rich repeat-containing protein 15; Leucine-rich repeat protein induced by beta-amyloid homolog (hLib); LRRC15; LIB

Function

(Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein. Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells.

Product Specifications

Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial (Active) — (Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein. Purity >90%. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

(Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein (PubMed:36228039, PubMed:36735681, PubMed:36757924). Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells (PubMed:36228039, PubMed:36757924)

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Tissue Specificity

Expressed in brain and placenta (PubMed:11785964). Expressed in lung fibroblasts (PubMed:36228039, PubMed:36757924). Expressed in chodrocytes (PubMed:34702854)

Subunit

(Microbial infection) Interacts with human coronavirus SARS-CoV-2 spike protein (via RBD domain); the interaction is direct

Gene: LRRC15  |  Organism: Homo sapiens  |  Synonyms: Leucine-rich repeat protein induced by beta-amyloid homolog
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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