Recombinant Human Lysyl oxidase homolog 1 (LOXL1), Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 59.9kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Lysyl oxidase homolog 1 (LOXL1)

Recombinant Human Lysyl oxidase homolog 1 (LOXL1) — Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elasti… Purity >85%.

SKU: BCRECP-001079 Categories: ,
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Product Specifications

Product SkuBCRECP-001079
Product DescriptionRecombinant Human Lysyl oxidase homolog 1 (LOXL1) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 95-574aa. [Accession | Q08397].
Uniprot No.Q08397
Gene NamesLOXL1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region95-574aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight59.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMetabolism

Function

Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. Essential for the elastic fiber homeostasis and for their maintenance at adult age.

Biological Context

Subcellular Location: Secreted, extracellular space; Secreted, extracellular space, extracellular matrix
Tissue Specificity: Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina
Disease Association: Exfoliation syndrome (XFS) : A disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. [Disease susceptibility is associated with variants affecting the gene represented in this entry. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations]

Product Specifications

Recombinant Human Lysyl oxidase homolog 1 (LOXL1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 95-574aa, with C-terminal 6xHis-tagged tag, molecular weight 59.9kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers (By similarity). Essential for the elastic fiber homeostasis and for their maintenance at adult age (By similarity)

Subcellular Location

Secreted, extracellular space; Secreted, extracellular space, extracellular matrix

Disease Association

Exfoliation syndrome (XFS) : A disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. [Disease susceptibility is associated with variants affecting the gene represented in this entry. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations]

Tissue Specificity

Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina

Subunit

Interacts (via propeptide) with EFEMP2 (PubMed:27339457). Interacts with FBLN5 (By similarity)

Gene: LOXL1  |  Organism: Homo sapiens  |  Synonyms: Lysyl oxidase-like protein 1
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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