Recombinant Human Melanoma-associated antigen 4 (MAGEA4) (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 36.7 kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Melanoma-associated antigen 4 (MAGEA4) (Active)

Recombinant Human Melanoma-associated antigen 4 (MAGEA4) (Active) — Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Purity >90%.

SKU: BCACP-000175 Category:
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Product SKUBCACP-000175
Product DescriptionRecombinant Human Melanoma-associated antigen 4 (MAGEA4) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 1-317aa. [Accession | P43358].
Uniprot No.P43358
Gene NamesMAGEA4
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region1-317aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight36.7 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/mL can bind anti-ANGPT2 recombinant antibody, the EC50 is 0.6666-0.8876 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(Cancer/testis antigen 1.4) (CT1.4) (MAGE-4 antigen) (MAGE-41 antigen) (MAGE-X2 antigen)

Function

Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.

Biological Context

Tissue Specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta

Product Specifications

Recombinant Human Melanoma-associated antigen 4 (MAGEA4) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 1-317aa, with C-terminal 10xHis-tagged tag, molecular weight 36.7 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/mL can bind anti-ANGPT2 recombinant antibody, the EC50 is 0.6666-0.8876 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486). Also negatively regulates p53-mediated apoptosis (PubMed:22842486)

Tissue Specificity

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta

Gene: MAGEA4  |  Organism: Homo sapiens  |  Synonyms: Cancer/testis antigen 1.4; MAGE-4 antigen; MAGE-41 antigen; MAGE-X2 antigen
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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