Recombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2), Partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 24.8kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2), Partial

Recombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2), Partial — Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Purity >85%.

SKU: BCRECP-001377 Category:
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Product Specifications

Product SkuBCRECP-001377
Product DescriptionRecombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 67-223aa. [Accession | O15173].
Uniprot No.O15173
Gene NamesPGRMC2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region67-223aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight24.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus.

Biological Context

Subcellular Location: Membrane (Single-pass membrane protein); Nucleus envelope; Endoplasmic reticulum; Secreted
Tissue Specificity: Expressed by endometrial glands and stroma (at protein level). Detected in urine (at protein level)

Product Specifications

Recombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2), Partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 67-223aa, with C-terminal 6xHis-tagged tag, molecular weight 24.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity)

Subcellular Location

Membrane (Single-pass membrane protein); Nucleus envelope; Endoplasmic reticulum; Secreted

Tissue Specificity

Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Detected in urine (at protein level) (PubMed:37453717)

Subunit

Interacts with PGRMC1 (By similarity). Interacts with AAAS (PubMed:27754849)

Gene: PGRMC2  |  Organism: Homo sapiens  |  Synonyms: Progesterone membrane-binding protein; Steroid receptor protein DG6
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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