Recombinant Human Mitochondrial-processing peptidase subunit alpha (PMPCA), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 60.6kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Mitochondrial-processing peptidase subunit alpha (PMPCA)

Recombinant Human Mitochondrial-processing peptidase subunit alpha (PMPCA) — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-001410 Categories: , ,
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Product Specifications

Product SkuBCRECP-001410
Product DescriptionRecombinant Human Mitochondrial-processing peptidase subunit alpha (PMPCA) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 34-525aa. [Accession | Q10713].
Uniprot No.Q10713
Gene NamesPMPCA
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region34-525aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight60.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasTags & Cell Markers

Function

Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

Biological Context

Subcellular Location: Mitochondrion matrix; Mitochondrion inner membrane
Tissue Specificity: Ubiquitously expressed with highest expression in fetal tissues and adult brain, cerebellum and cerebellar vermis
Disease Association: Spinocerebellar ataxia, autosomal recessive, 2 (SCAR2) : A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR2 is characterized by onset of impaired motor development and ataxic gait in early childhood. Additional features often include loss of fine motor skills, dysarthria, nystagmus, cerebellar signs, and delayed cognitive development with intellectual disability. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Mitochondrial-processing peptidase subunit alpha (PMPCA) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 34-525aa, with N-terminal 6xHis-tagged tag, molecular weight 60.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins

Subcellular Location

Mitochondrion matrix; Mitochondrion inner membrane

Disease Association

Spinocerebellar ataxia, autosomal recessive, 2 (SCAR2) : A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR2 is characterized by onset of impaired motor development and ataxic gait in early childhood. Additional features often include loss of fine motor skills, dysarthria, nystagmus, cerebellar signs, and delayed cognitive development with intellectual disability. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Ubiquitously expressed with highest expression in fetal tissues and adult brain, cerebellum and cerebellar vermis

Subunit

Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit

Gene: PMPCA  |  Organism: Homo sapiens  |  Synonyms: Alpha-MPP; Inactive zinc metalloprotease alpha; P-55
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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