Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3), partial, Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 16.2kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3), partial

Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3), partial — Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Purity >95%.

SKU: BCRECP-001227 Category:
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Product Specifications

Product SkuBCRECP-001227
Product DescriptionRecombinant Human Natural cytotoxicity triggering receptor 3 (NCR3) Protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 1-135aa. [Accession | O14931].
Uniprot No.O14931
Gene NamesNCR3
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region1-135aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight16.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Selectively expressed by all resting and activated NK cells and weakly expressed in spleen

Product Specifications

Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3), partial is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 1-135aa, with C-terminal 10xHis-tagged tag, molecular weight 16.2kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Tissue Specificity

Selectively expressed by all resting and activated NK cells and weakly expressed in spleen

Subunit

Homodimer in the unliganted form (PubMed:21422170, PubMed:21444796). Interacts with CD3Z (PubMed:10562324, Ref.2). Interacts with and is activated by binding to NCR3LG1 (PubMed:19528259, PubMed:21422170, PubMed:21444796). Interacts with and is activated by binding to BAG6 (PubMed:18055229, PubMed:18852879). Interacts with and is inhibited by binding to LGALS3 (PubMed:25315772)

Gene: NCR3  |  Organism: Homo sapiens  |  Synonyms: Activating natural killer receptor p30; Natural killer cell p30-related protein
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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