Recombinant Human Neurotrophic factor BDNF precursor form (BDNF) (Active), Homo sapiens (Human), E.coli, Tag-Free, 13 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Neurotrophic factor BDNF precursor form (BDNF) (Active)

Recombinant Human Neurotrophic factor BDNF precursor form (BDNF) (Active) — Important signaling molecule that activates signaling cascades downstream of NTRK2. Purity >95%.

SKU: BCACP-001197 Categories: ,
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Product SKUBCACP-001197
Product DescriptionRecombinant Human Neurotrophic factor BDNF precursor form (BDNF) protein is expressed from E.coli with Tag-Free. It contains 129-247aa. [Accession | P23560].
Uniprot No.P23560
Gene NamesBDNF
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region129-247aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight13 kDa
ActivityThe ED50 as determined in a cell proliferation assay using Balb/3T3 mouse fibroblast cells is 0.1-0.6 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesAbrineurin; ANON2; BDNF; BDNF_HUMAN; Brain Derived Neurotrophic Factor; Brain-derived neurotrophic factor; BULN2; MGC34632; Neurotrophin

Function

Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD).

Product Specifications

Recombinant Human Neurotrophic factor BDNF precursor form (BDNF) (Active) is a recombinant protein, expressed in E.coli, covering amino acids 129-247aa, with Tag-Free tag, molecular weight 13 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: The ED50 as determined in a cell proliferation assay using Balb/3T3 mouse fibroblast cells is 0.1-0.6 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity)

Gene: BDNF  |  Organism: Homo sapiens

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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