Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 20.0 kDa, purity >95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.

Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) (Active)

Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) (Active) — Functions as a lectin that binds to selective commensal dental plaque bacteria, such as Streptococcus vestibularis. Purity >95%.

SKU: BCACP-000193 Category:
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Product SKUBCACP-000193
Product DescriptionRecombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 53-208aa. [Accession | Q96DA0].
Uniprot No.Q96DA0
Gene NamesZG16B
PurityGreater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region53-208aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight20.0 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human CLDN9 at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody , the EC50 is 24.93-35.47 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Functions as a lectin that binds to selective commensal dental plaque bacteria, such as Streptococcus vestibularis. Contributes to maintain homeostasis in the oral microbiome by capturing commensal microbes and regulating their growth using a mucin-assisted clearance mechanism. Plays an important role in pancreatic tumor progression and metastasis.

Biological Context

Subcellular Location: Secreted; Cytoplasm; Cell membrane; Apicolateral cell membrane
Tissue Specificity: Highly expressed in pancreatic cancer tissues (at protein levels). Also expressed in the placenta and colon and ovarian cancer tumors. Highly expressed in salivary glands, in submandibular and sublingual glands

Product Specifications

Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 53-208aa, with C-terminal 10xHis-tagged tag, molecular weight 20.0 kDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Functions as a lectin that binds to selective commensal dental plaque bacteria, such as Streptococcus vestibularis. Contributes to maintain homeostasis in the oral microbiome by capturing commensal microbes and regulating their growth using a mucin-assisted clearance mechanism (PubMed:37216558). Plays an important role in pancreatic tumor progression and metastasis (PubMed:19302292, PubMed:36232715). Promotes pancreatic cancer cells migration and invasion through the TLR4/MyD88/NF-kappaB signaling pathway, without the involvement of the TLR4/TRIF pathway (PubMed:36232715)

Subcellular Location

Secreted; Cytoplasm; Cell membrane; Apicolateral cell membrane

Tissue Specificity

Highly expressed in pancreatic cancer tissues (at protein levels). Also expressed in the placenta and colon and ovarian cancer tumors (PubMed:19302292). Highly expressed in salivary glands, in submandibular and sublingual glands (PubMed:33207190)

Subunit

Interacts with MUC7; this interaction enhances the capture of commensal bacteria and promotes their removal via the mucin-assisted clearance pathway (PubMed:37216558). Found in a complex with the salivary mucin MUC7 and with Streptococcus vestibularis (PubMed:37216558)

Gene: ZG16B  |  Organism: Homo sapiens  |  Synonyms: Zymogen granule protein 16 homolog B
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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