Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 21.2kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B)

Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) — Functions as a lectin that binds to selective commensal dental plaque bacteria, such as Streptococcus vestibularis. Purity >90%.

SKU: BCRECP-001936 Category:
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Product Specifications

Product SkuBCRECP-001936
Product DescriptionRecombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 53-208aa. [Accession | Q96DA0].
Uniprot No.Q96DA0
Gene NamesZG16B
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region53-208aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight21.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Functions as a lectin that binds to selective commensal dental plaque bacteria, such as Streptococcus vestibularis. Contributes to maintain homeostasis in the oral microbiome by capturing commensal microbes and regulating their growth using a mucin-assisted clearance mechanism. Plays an important role in pancreatic tumor progression and metastasis.

Biological Context

Subcellular Location: Secreted; Cytoplasm; Cell membrane; Apicolateral cell membrane
Tissue Specificity: Highly expressed in pancreatic cancer tissues (at protein levels). Also expressed in the placenta and colon and ovarian cancer tumors. Highly expressed in salivary glands, in submandibular and sublingual glands

Product Specifications

Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 53-208aa, with N-terminal 6xHis-tagged tag, molecular weight 21.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Functions as a lectin that binds to selective commensal dental plaque bacteria, such as Streptococcus vestibularis. Contributes to maintain homeostasis in the oral microbiome by capturing commensal microbes and regulating their growth using a mucin-assisted clearance mechanism (PubMed:37216558). Plays an important role in pancreatic tumor progression and metastasis (PubMed:19302292, PubMed:36232715). Promotes pancreatic cancer cells migration and invasion through the TLR4/MyD88/NF-kappaB signaling pathway, without the involvement of the TLR4/TRIF pathway (PubMed:36232715)

Subcellular Location

Secreted; Cytoplasm; Cell membrane; Apicolateral cell membrane

Tissue Specificity

Highly expressed in pancreatic cancer tissues (at protein levels). Also expressed in the placenta and colon and ovarian cancer tumors (PubMed:19302292). Highly expressed in salivary glands, in submandibular and sublingual glands (PubMed:33207190)

Subunit

Interacts with MUC7; this interaction enhances the capture of commensal bacteria and promotes their removal via the mucin-assisted clearance pathway (PubMed:37216558). Found in a complex with the salivary mucin MUC7 and with Streptococcus vestibularis (PubMed:37216558)

Gene: ZG16B  |  Organism: Homo sapiens  |  Synonyms: Zymogen granule protein 16 homolog B
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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