Recombinant Human POU domain, class 2, transcription factor 3 (POU2F3), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged, 53.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human POU domain, class 2, transcription factor 3 (POU2F3)

Recombinant Human POU domain, class 2, transcription factor 3 (POU2F3) — Transcription factor that binds to the octamer motif (5′-ATTTGCAT-3′) and regulates cell type-specific differentiation pathways. Purity >90%.

SKU: BCRECP-001420 Category:
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Product Specifications

Product SkuBCRECP-001420
Product DescriptionRecombinant Human POU domain, class 2, transcription factor 3 (POU2F3) Protein is expressed from E.coli with N-terminal 10xHis-tagged. It contains 1-436aa. [Accession | Q9UKI9].
Uniprot No.Q9UKI9
Gene NamesPOU2F3
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-436aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight53.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation. The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Specifically expressed in epidermis and cultured keratinocytes

Product Specifications

Recombinant Human POU domain, class 2, transcription factor 3 (POU2F3) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-436aa, with N-terminal 10xHis-tagged tag, molecular weight 53.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971)

Subcellular Location

Nucleus

Tissue Specificity

Specifically expressed in epidermis and cultured keratinocytes

Subunit

Interacts (via the POU domain) with POU2AF1 and POU2AF2 in a DNA-dependent manner; this interaction recruits POU2AF2 to chromatin and increases POU2F3 transactivation activity

Gene: POU2F3  |  Organism: Homo sapiens  |  Synonyms: Octamer-binding protein 11; Octamer-binding transcription factor 11; Transcription factor PLA-1; Transcription factor Skn-1
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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