Recombinant Human Pro-epidermal growth factor (EGF)，Partial (Active), Homo sapiens (Human), Mammalian cell, Tag free, 6.2 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Pro-epidermal growth factor (EGF)，Partial (Active)

Recombinant Human Pro-epidermal growth factor (EGF)，Partial (Active) — EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Purity >95%.

SKU: BCACP-001119 Categories: ,
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Product SKUBCACP-001119
Product DescriptionRecombinant Human Pro-epidermal growth factor (EGF)，Partial protein is expressed from Mammalian cell with Tag free. It contains 971-1023aa. [Accession | P01133].
Uniprot No.P01133
Gene NamesEGF
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region971-1023aa
SpeciesHomo sapiens (Human)
Tag InfoTag free
Molecular weight6.2 kDa
ActivityMeasured in a cell proliferation assay using Mv.1.Lu Mink lung epithelial cells. The ED50 for this effect is ≤10 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesPro-Epidermal Growth Factor; EGF; Epidermal Growth Factor; Urogastrone

Function

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein)
Tissue Specificity: Expressed in kidney, salivary gland, cerebrum and prostate
Disease Association: Hypomagnesemia 4 (HOMG4) : A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Pro-epidermal growth factor (EGF)，Partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 971-1023aa, with Tag free tag, molecular weight 6.2 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured in a cell proliferation assay using Mv.1.Lu Mink lung epithelial cells. The ED50 for this effect is ≤10 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941)

Subcellular Location

Membrane (Single-pass type I membrane protein)

Disease Association

Hypomagnesemia 4 (HOMG4) : A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in kidney, salivary gland, cerebrum and prostate

Subunit

Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD)

Gene: EGF  |  Organism: Homo sapiens
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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