Recombinant Human Pro-epidermal growth factor (EGF), partial (Active)

Function

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941)

Subcellular Location

Membrane (Single-pass type I membrane protein)

Disease Association

Hypomagnesemia 4 (HOMG4) : A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in kidney, salivary gland, cerebrum and prostate

Subunit

Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD)

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• PubMed: CI-9GAL73TV64VE7 (DEC-)
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• Halim A. et al. Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. — Mol. Cell. Proteomics (2012)