Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 49.8kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)

Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) — DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Purity >90%.

SKU: BCRECP-000108 Categories: ,
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Product Specifications

Product SkuBCRECP-000108
Product DescriptionRecombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-190aa. [Accession | Q9NRW3].
Uniprot No.Q9NRW3
Gene NamesAPOBEC3C
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-190aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight49.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.

Biological Context

Subcellular Location: Nucleus; Cytoplasm
Tissue Specificity: Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary

Product Specifications

Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-190aa, with N-terminal GST-tagged tag, molecular weight 49.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation

Subcellular Location

Nucleus; Cytoplasm

Tissue Specificity

Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary

Subunit

(Microbial infection) Interacts with HIV-1 Vif

Gene: APOBEC3C  |  Organism: Homo sapiens  |  Synonyms: APOBEC1-like; Phorbolin I
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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